2. Signaling Pathways
  3. Epigenetics
  4. Epigenetic Reader Domain
  5. Epigenetic Reader Domain Chemical

Epigenetic Reader Domain Chemical

Epigenetic Reader Domain Chemicals (2):

Cat. No. Product Name Effect Purity
  • HY-149761
    GSK023
    		Chemical
    GSK023 (compound 31) is a selective chemical probe targeting the BET BD1 domain.
  • HY-P11661
    DC-peptoid-1
    		Chemical
    DC-peptoid-1 is a specific binder and crosslinker targeting the phosphorylated Brd4 PDID domain, with a dissociation constant (Kd) of approximately 50-100 μM for human-derived targets. DC-peptoid-1 only binds to phosphorylated PDID and fails to recognize the non-phosphorylated form or other domains (such as Brd4 598-785). DC-peptoid-1 effectively crosslinks with the target protein both in solution and cell lysates. It can successfully capture phosphorylated PDID from complex systems via immobilization, without binding to bacterial-derived non-phosphorylated proteins or other non-specific phosphoproteins. DC-peptoid-1 has the potential to serve as a phosphoprotein-specific antibody substitute for applications such as immunoaffinity purification.